![]() ![]() In aqueous environments, viruses float free in the water.Ĭurrently, there are limited options in the treatment of viral conditions. Released virions can be passed between hosts either through direct contact, often via body fluids, or through a vector. Virusses use the machinery and metabolism of the host cell to produce multiple copies of themselves via a lytic and/or a lysogenic cycle. Subsequently, the virus is taken up by the cell either by means of direct cell membrane fusion (using cell penetrating peptides), or by via an endocytotic vesicle. To enter a cell, a virus attaches to the cell surface via binding to a specific receptor. At the most basic level, viruses consist of genetic material, DNA and/or RNA, contained within a protective protein coat called a capsid. Viruses can only replicate by infecting a host cell and therefore cannot reproduce on their own. BACKGROUND OF THE INVENTIONĪ virus is a microscopic particle that can infect the cells of an organism. These conjugates are used in methods for treatment or prevention of viral infections and related conditions. The invention relates to conjugates of antiviral agents, optionally comprised in a pharmaceutical acceptable carrier, with ligands for receptors that mediate endo- or transcytosis. The effect itself has a Proc Coefficient of zero, and cannot score a Critical Hit (increasing flat damage proportionally to the Critical Hit chance and damage instead).This invention relates to the field of targeted drug delivery. This gem is of most use to Physical skill builds. If an enemy bleeds from more than one source, it will still only grant one stack of Blood Frenzy. This includes enemies that are under any Bleed effect (not just the Pain Enhancer's own Bleed) applied by that player, pets/minions, and follower. ![]() Upgrading increases total damage done (and damage per tick).Īt rank 25, it also increases Attack Speed for every bleeding enemy close to the player. The effect can be applied by your pets/minions and follower. Each Critical Hit, regardless of Proc Coefficient, applies one, but they do not stack, only being renewed to full duration. This gem causes Critical Hits to apply a Bleed effect to the enemy. It can only be socketed into Amulets and Rings, and drops from Greater Rift Guardians. Pain Enhancer is a Legendary Gem in Diablo III. ![]()
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